Beginning on January 30th, the exhibition will tell six different design stories in set areas of design including furniture, products, fashion, transport and architecture.
It is a semi-permanent show that will remain open to visitors to central London hotels until the start of 2015 and is accompanied by a Design Museum Collection App for those with iPhones and iPads that will provide more information on the range of items featured in the show.
The idea that design can help create a national identity will be discussed in the show, with objects such as phone boxers, road signs and the London 2012 Logo all being exhibited as part of the definition of being British.
Fashion collector Jill Ritblat has also learnt the museum a number of items from her wardrobe to look at the changing clothing trends during the 1970s, 1980s and 1990s.
Deyan Sudjic, director of the Design Museum explained: "Design matters at every level. It is what makes daily life a little better; it is about the big economic changes that the world is going through.
"It is about the designers and the manufacturers, but it is also about the users. It is a unique way of making sense of the world around us."
Entry to the Design Museum costs £11 for adults and is free to those aged under 12.
The museum is located just 15 minutes' walk from London Bridge national rail and underground stations and was established by Terence Conrad in 1990. Since then it has showcased a number of ground-breaking exhibits and designs.